Table 1 Summary of gene pathways statistically enriched in the hearts 8 months post-pregnancy.
From: Long-term cardiovascular disorders in the STOX1 mouse model of preeclampsia
Gene Set | Description | Size | Expect | Ratio | P Value | FDR |
|---|---|---|---|---|---|---|
Up-regulated genes | ||||||
GO: Biological Process | ||||||
GO:0070972 | protein localization to endoplasmic reticulum | 137 | 0.619 | 20.97 | 3.37e-14 | 2.86e-11 |
GO:0006413 | translational initiation | 192 | 0.868 | 14.96 | 2.67e-12 | 1.13e-9 |
GO:0014812 | muscle cell migration | 79 | 0.357 | 13.98 | 0 | 0.0034 |
GO:0006631 | fatty acid metabolic process | 357 | 1.615 | 4.333 | 0.001 | 0.095 |
GO:Celular Components | ||||||
GO:0005840 | ribosome | 229 | 1.340 | 13.42 | 4.44e-16 | 7.63e-14 |
GO:0098798 | mitochondrial protein complex | 266 | 1.557 | 5.78 | 0 | 0.001 |
GO:0070469 | respiratory chain | 100 | 0.585 | 10.25 | 0 | 0.001 |
GO:0030055 | cell-substrate junction | 411 | 2.405 | 3.74 | 0.0006 | 0.016 |
Pathways | ||||||
hsa03010 (K) | Ribosome | 153 | 1.003 | 15.94 | 8.88e-16 | 2.89e-13 |
hsa00190 (K) | Oxidative phosphorylation | 133 | 0.872 | 6.87 | 0.00020 | 0.019 |
hsa00980 (K) | Metabolism of xenobiotics by cytochrome P450 | 76 | 0.498 | 8.02 | 0.0015 | 0.069 |
hsa05418 (K) | Fluid shear stress and atherosclerosis | 139 | 0.911 | 5.48 | 0.0021 | 0.074 |
WP477 (W) | Cytoplasmic Ribosomal Proteins | 91 | 0.685 | 18.97 | 5.20e-14 | 2.28e-11 |
WP623 (W) | Oxidative phosphorylation | 62 | 0.466 | 8.57 | 0.0011 | 0.12 |
Down-regulated genes | ||||||
GO:Biological Process | ||||||
GO:1901652 | response to peptide | 487 | 1.24 | 7.20 | 0.0000029 | 0.0025 |
GO:0006631 | fatty acid metabolic process | 357 | 0.91 | 7.64 | 0 | 0.0126 |
GO:0071887 | leukocyte apoptotic process | 107 | 0.27 | 14.56 | 0.00020 | 0.0334 |
GO:0022407 | regulation of cell-cell adhesion | 383 | 0.98 | 6.10 | 0.00040 | 0.0421 |
GO:0048545 | response to steroid hormone | 388 | 0.99 | 6.02 | 0.00040 | 0.0421 |
Pathways | ||||||
WP619 (W) | Type II interferon signaling (IFNG) | 37 | 0.14 | 40.50 | 4.6234e-9 | 0.0000020 |
R-HSA-877300 (R) | Interferon gamma signaling | 92 | 0.27 | 18.50 | 0.0000064 | 0.011 |
hsa04621 (K) | NOD-like receptor signaling pathway | 168 | 0.67 | 8.89 | 0 | 0.012 |
hsa04620 (K) | Toll-like receptor signaling pathway | 104 | 0.41 | 9.57 | 0.00070 | 0.06 |
