Figure 4

Antimalarial drug treatments do not change susceptibility to Py infection. Mice were treated with antimalarials followed by Py infection at 21 days p.t. (A) Percent parasitemia on the indicated day post infection (p.i.). (B) Area under the parasitemia curve (AUC) quantifying overall parasite burden (day 0–33 p.i.) during Py infection for each treatment group. (C) AUC quantifying parasite burden through peak infection (day 0–19 p.i.) for each treatment group. (A–C) Data (mean±S.E.) are the cumulative results of 2 experiments (4 mice/group/experiment). Data in (A) were analyzed by one-way ANOVA at each time point p.i.; *p < 0.05. Data in (B) were analyzed by one-way. ANOVA with Tukey’s multiple comparisons test; *p < 0.05.