Table 3 Chi-square analyses for the frequency of relevant dysregulation in the downstream target RNAs.
From: Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer’s disease model
Targeted by dysregulated upstream miRNAs | Dysregulation of downstream mRNAs | Odds Ratio† | 95% Confidence interval | P value |
|---|---|---|---|---|
A | ||||
7 M up-regulated miRNAs | Down-regulation | 1.123 | 0.950–1.327 | 0.175 |
7 M down-regulated miRNAs | Up-regulation | 0.495 | 0.304–0.806 | 0.004* |
12 M up-regulated miRNAs | Down-regulation | 0.722 | 0.563–0.926 | 0.010* |
12 M down-regulated miRNAs | Up-regulation | 0.763 | 0.543–1.073 | 0.119 |
Targeted by dysregulated upstream circRNAs | Dysregulation of downstream miRNAs | Odds Ratio | 95% Confidence interval | P value |
B | ||||
7 M up-regulated circRNAs | Down-regulation | 0.484 | 0.063–3.739 | 0.478 |
7 M down-regulated circRNAs | Up-regulation | 1.065 | 0.436–2.604 | 0.889 |
12 M up-regulated circRNAs | Down-regulation | — | — | 1.000 |
12 M down-regulated circRNAs | Up-regulation | 4.037 | 0.362–45.025 | 0.260 |
