Table 4 Analyses for the effect of dysregulated circRNAs on the expression of their downstream target mRNAs.

From: Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer’s disease model

Targeted by dysregulated upstream circRNAs

Dysregulation of downstream mRNAs

Odds Ratio

95% Confidence interval

P value

A

7 M up-regulated circRNAs

Up-regulation

8.535

7.017–10.381

<0.001**

7 M down-regulated circRNAs

Down-regulation

6.977

5.993–8.123

<0.001**

12 M up-regulated circRNAs

Up-regulation

1.413

1.049–1.903

0.039*

12 M down-regulated circRNAs

Down-regulation

17.578

8.897–34.727

<0.001**

Dysregulation of mRNAs

 

Odds Ratio

95% Confidence interval

P value

B

7 M up-regulation

Targeted by 7 M up-regulated circRNAs

12.425

10.178–15.169

<0.001**

7 M down-regulation

Targeted by 7 M down-regulated circRNAs

37.279

30.275–45.903

<0.001**

12 M up-regulation

Targeted by 12 M up-regulated circRNAs

1.413

1.049–1.903

0.039*

12 M down-regulation

Targeted by 12 M down-regulated circRNAs

22.081

10.996–44.344

<0.001**

  1. Univariate (chi-square) analyses were summarized in Table A. In Table B, logistic analyses demonstrate the effect of dysregulated circRNAs on the relevant dysregulation of their downstream target mRNAs, after adjusting the effects of dysregulated miRNAs. *P < 0.05 and **P < 0.01.
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