Table 6 Five most enriched gene ontology (GO) processes and KEGG pathway of down-regulated mRNAs in Alzheimer’s disease model.

GO biological process

Fold Enrichment

P value

GO biological process

Fold Enrichment

P value

Muscle cell fate commitment

49.3

0.040

Cytokine-mediated signaling pathway

0.026

42.1

Negative regulation of muscle hyperplasia

49.3

0.040

Mesenchymal to epithelial transition involved in metanephros morphogenesis

0.027

31.8

Schwann cell proliferation

32.8

0.030

Positive regulation of action potential

0.042

25.8

Regulation of store-operated calcium entry

14.8

0.017

—

—

—

Mitochondrial genome maintenance

13.4

0.020

—

—

—

GO molecular function

GO molecular function

Structural constituent of bone

47.2

0.001

Inward rectifier potassium channel activity

24.6

0.007

cAMP response element binding protein binding

20.2

0.009

Voltage-gated ion channel activity

9.2

0.002

Enhancer binding

12.9

0.022

Cytokine activity

4.6

0.045

Anion transmembrane transporter activity

7.4

0.040

—

—

—

Transcription factor activity, RNA polymerase II

4.4

0.012

—

—

—

GO cellular component

GO cellular component

Signal recognition particle

24.1

0.040

Voltage-gated potassium channel complex

9.6

0.038

Transcription elongation factor complex

8.4

0.011

axoneme

9

0.043

Trans-Golgi network membrane

6.9

0.049

Receptor complex

7.5

0.016

polysome

5.6

0.012

—

—

—

Transcription factor complex

3.1

<0.001

—

—

—

Pathway analysis

Pathway analysis

Pantothenate and CoA biosynthesis

8.4

0.049

Retrograde endocannabinoid signaling

11.5

0.004

Arginine and proline metabolism

4.1

0.043

Cholinergic synapse

10.5

0.006

Glucagon signaling pathway

3.0

0.048

—

—

—

Glutamatergic synapse

2.6

0.038

—

—

—

PI3K-Akt signaling pathway

2.6

0.001

—

—

—