Figure 6
From: Lyssavirus matrix protein cooperates with phosphoprotein to modulate the Jak-Stat pathway
Dynamic interactions between RABV P and/or M proteins and pSTAT1 and Jak1 proteins. Protein complementation assay: P and M proteins were co-transfected with STAT1 or JAK1-coding plasmids. Two days post-transfection, cells were stimulated with IFNα for 15 or 30 min, or 1, 2, 4, 8 or 24 h. Gaussia luciferase activity, whose intensity corresponds to interaction, was determined. The bold horizontal lines represent the Gaussia significance threshold. Results are expressed as means ± standard deviation (T-bars) of five independent experiments.
