Figure 1

Receiver operating characteristic (ROC) curve analysis to determine cut-off body mass index (BMI) values for predicting the development of nausea and diarrhea in patients with idiopathic pulmonary fibrosis receiving nintedanib treatment. Sensitivity is plotted on the y-axis and specificity on the x-axis. (A) The area under the curve (AUC) is equivalent to the numerator of the Mann-Whitney U statistic comparing the marker distributions for the development of nausea [AUC, 0.873; 95% confidence interval (CI), 0.784–0.962; p = 0.001]. The optimal cut-off value is 21.6 kg/m², with sensitivity, specificity, and likelihood ratios of 68.0%, 84.7%, and 4.533, respectively. (B) AUC is equivalent to the numerator of the Mann-Whitney U statistic comparing the marker distributions for the development of diarrhea (AUC, 0.668; 95% CI, 0.502–0.834; p = 0.036). The optimal cut-off value is 21.6 kg/m², with sensitivity, specificity, and likelihood ratios of 60.8%, 80.1%, and 3.156, respectively.