Table 1 Gene expression of fibroblasts treated with a 940 nm diode laser at 0.5 Watts and 4 J/cm², following two treatment protocols: one dose (T1) and two doses (T2).

Gen	Treatment	Mean	Standard Deviation	p value
FGF	Control	601.45	68.44
	T1	1924.05	349.99	0.05*
	T2	1046.69	117.88	0.05*
	T1 Vs T2			0.513
CTGF	Control	710.4	582.65
	T1	909.96	483.99	0.497
	T2	167.73	130.26	0.042*
	T1 Vs T2			0.043*
VEGF	Control	41.9	0.73
	T1	41.25	1.46	0.658
	T2	53.55	6.1	0.05*
	T1 Vs T2			0.05*
TGF-β1	Control	40272.68	1564.55
	T1	77088.78	3480.91	0.05*
	T2	54227.56	3255.26	0.05*
	T1 Vs T2			0.275
TGFβR1	Control	44943.09	800.95
	T1	59638.95	5223.23	0.05*
	T2	65203.3	610.3	0.05*
	T1 Vs T2			0.268
TGFβR2	Control	85792.51	3856.83
	T1	119296.52	7411.73	0.002*
	T2	174964.17	2677.26	0.000*
	T1 Vs T2			0.05*
TGFβR3	Control	102466.73	55209.72
	T1	86085.74	9883.43	0.497
	T2	116559.82	19233.12	0.661
	T1 Vs T2			0.014*
α-actin	Control	1.23	0.35
	T1	3.5	0.37	0.034*
	T2	4.84	1.11	0.021*
	T1 Vs T2			0.034*
fibronectin	Control	1649.99	428.63
	T1	11576.43	276.38	0.05*
	T2	4893.05	529.88	0.05*
	T1 Vs T2			0.05*
decorin	Control	514.9	67.89
	T1	702.46	62.83	0.05*
	T2	976.28	59.02	0.05*
	T1 Vs T2			0.001*
elastin	Control	488.14	37.52
	T1	419.71	22.39	0.05*
	T2	140.3	17.04	0.05*
	T1 Vs T2			0.05*
DDR2	Control	48.39	2.87
	T1	53.81	3.49	0.05*
	T2	59.72	4.02	0.05*
	T1 Vs T2			0.05*
MMP2	Control	1270.19	99.45
	T1	1691.09	152.54	0.034*
	T2	2002.29	233.74	0.034*
	T1 Vs T2			0.05*

FGF, fibroblast growth factor; CTGF, connective tissue growth factor; VEGF, vascular endothelial growth factor; TGF-β1, transforming growth factor β1; TGFβR1, transforming growth factor β-receptor 1; TGFβR2, transforming growth factor β-receptor 2; TGFβR3, transforming growth factor β-receptor 3; DDR2, discoidin domain receptor 2; MMP2, matrix metalloproteinase-2. Data are expressed as mean of ng of mRNA per average ng of housekeeping mRNAs and Standard Deviation. *p ≤ 0.05.

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