Figure 6
From: Exhaustion of CD4+ T-cells mediated by the Kynurenine Pathway in Melanoma
Correlation-based network analysis of CD4+ T-cells and KP metabolites-related genes in V600E and BRAF wt SKCM (a) correlation networks between CD4+ T-cells and KP metabolites-related signature genes in BRAF V600E SKCM and in (b) BRAF wt SKCM (c) DyNet visualization of union correlation network of CD4+ T-cells and KP metabolites-related signature genes; the pink edges are present only in the case of BRAF wt; green edges are present only in BRAF V600E; light purple edges are present in both. DyNet highlights the most rewired nodes. More red nodes with higher varying edge connections via the betweenness score (d–f); arrows indicate different genes, black; KYNU, orange; KMO, olive; IDO1, blue; TGFβ1, purple; IDO2. CC; average clustering coefficient, AveSPL; average shortest path length.
