Table 2 Analysis of FANCC variants (p.R158X and p.R548X combined) by tumour subtype.

From: Two truncating variants in FANCC and breast cancer risk

Stratum

Cases

Odds Ratio (95% CI)

p

ER-negative

5/10,124

0.91 (0.35; 2.37)

0.845

ER-positive

14/40,855

0.67 (0.37; 1.28)

0.223

TNBC

2/4,126

0.89 (0.21; 3.77)

0.877

Ductal

6/36,695

0.33 (0.13; 0.80)

0.014

Lobular

4/6,842

1.27 (0.43; 3.69)

0.665

High grade

3/14,582

0.39 (0.12; 1.31)

0.129

Node-positive

1/15,937

0.14 (0.02; 1.00)

0.050

Familial

7/9,720

1.01 (0.43; 2.35)

0.988

Premenopausal

12/22,232

1.09 (0.55; 2.16)

0.814

Bilateral

0/2,741

—

0.645

  1. Association analyses of FANCC variants p.R158X and p.R548X with breast cancer risk for subgroups. Results are given as odds ratios (OR) with 95% confidence interval (CI) and p-value (p). Cases in subgroups were compared to the frequency 26/ 49,793 for all controls (derived from Table 1). Familial cases were defined as those with a first-degree family history of breast cancer; premenopausal cases were those with age at diagnosis <50 years. ER, estrogen-receptor; TNBC, triple-negative breast cancer.
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