Table 5 Association of TCF7L2 SNPs with amygdala, hippocampus, gray matter and white matter hyperintensities (WMH) volume.

From: TCF7L2 polymorphisms are associated with amygdalar volume in elderly individuals with Type 2 Diabetes

TCF7L2 SNPs [T2D risk allele]	Genetic model	Regression model A				Regression model B
		Unstandardized Coefficients		Standardized Coefficients	p value	Unstandardized Coefficients		Standardized Coefficients	p value
		B	Std. Error	β	p value	B	Std. Error	β	p value
Amygdala
rs7901695 [C]	Additive	−0.018	0.008	−0.155	0.0270	−0.016	0.0080	−0.140	0.0450
	Recessive	−0.046	0.015	−0.208	0.0020	−0.043	0.015	−0.198	0.003
	Dominant	−0.011	0.012	−0.060	0.395	−0.008	0.012	−0.043	0.541
rs7903146 [T]	Additive	−0.018	0.008	−0.157	0.025	−0.017	0.008	−0.147	0.036
	Recessive	−0.044	0.015	−0.202	0.003	−0.042	0.015	−0.192	0.005
	Dominant	−0.013	0.012	−0.073	0.307	−0.011	0.012	−0.064	0.367
rs11196205 [C]	Additive	−0.023	0.008	−0.194	0.005	−0.022	0.008	−0.181	0.008
	Recessive	−0.048	0.013	−0.247	0.0003	−0.044	0.013	−0.226	0.001
	Dominant	−0.013	0.014	−0.066	0.343	−0.013	0.014	−0.067	0.333
rs12255372 [T]	Additive	−0.016	0.008	−0.134	0.054	−0.014	0.008	−0.118	0.090
	Recessive	−0.046	0.015	−0.203	0.003	−0.043	0.015	−0.191	0.005
	Dominant	−0.007	0.012	−0.039	0.585	−0.004	0.012	−0.021	0.762
Hippocampus
rs7901695 [C]	Additive	−0.003	0.004	−0.039	0.559	−0.002	0.004	−0.027	0.685
	Recessive	−0.010	0.008	−0.077	0.246	−0.009	0.008	−0.071	0.275
	Dominant	0.000	0.007	0.005	0.944	0.002	0.007	0.020	0.770
rs7903146 [T]	Additive	0.000	0.004	−0.002	0.978	0.000	0.004	0.004	0.950
	Recessive	−0.009	0.008	−0.069	0.300	−0.008	0.008	−0.066	0.317
	Dominant	0.005	0.007	0.055	0.425	0.006	0.007	0.061	0.363
rs11196205 [C]	Additive	−0.006	0.005	−0.085	0.205	−0.005	0.004	−0.069	0.287
	Recessive	−0.015	0.007	−0.141	0.035	−0.013	0.007	−0.121	0.064
	Dominant	0.001	0.008	0.005	0.938	0.001	0.007	0.010	0.885
rs12255372 [T]	Additive	0.001	0.005	0.015	0.822	0.002	0.004	0.032	0.628
	Recessive	−0.015	0.008	−0.116	0.079	−0.013	0.008	−0.101	0.121
	Dominant	0.011	0.007	0.115	0.090	0.013	0.007	0.130	0.052
Gray Matter
rs7901695 [C]	Additive	−2.602	2.974	−0.037	0.383	−2.509	2.955	−0.036	0.397
	Recessive	−7.397	5.451	−0.057	0.176	−7.223	5.366	−0.056	0.180
	Dominant	−0.937	4.497	−0.009	0.835	−0.759	4.481	−0.007	0.866
rs7903146 [T]	Additive	−1.939	2.902	−0.028	0.505	−1.997	2.884	−0.029	0.490
	Recessive	−6.473	5.419	−0.050	0.234	−6.448	5.364	−0.050	0.231
	Dominant	−0.216	4.413	−0.002	0.961	−0.333	4.388	−0.003	0.940
rs11196205 [C]	Additive	−4.048	3.034	−0.056	0.184	−3.580	2.987	−0.050	0.232
	Recessive	−9.779	4.830	−0.085	0.044	−8.626	4.767	−0.075	0.072
	Dominant	−0.667	5.099	−0.006	0.896	−0.640	5.019	−0.005	0.899
rs12255372 [T]	Additive	−2.323	2.987	−0.033	0.438	−2.085	2.969	−0.030	0.483
	Recessive	−9.199	5.640	−0.068	0.105	−8.193	5.564	−0.061	0.143
	Dominant	0.500	4.415	0.005	0.910	0.495	4.400	0.005	0.911
WMH
rs7901695 [C]	Additive	−0.149	1.428	−0.008	0.917	−0.042	1.441	−0.002	0.977
	Recessive	0.558	2.635	0.016	0.833	0.759	2.633	0.021	0.773
	Dominant	−0.709	2.147	−0.025	0.742	−0.611	2.171	−0.021	0.779
rs7903146 [T]	Additive	−1.130	1.131	−0.075	0.319	−1.131	1.130	−0.075	0.318
	Recessive	−1.822	2.139	−0.063	0.395	−1.755	2.128	−0.061	0.411
	Dominant	−1.394	1.699	−0.062	0.413	−1.423	1.692	−0.063	0.401
rs11196205 [C]	Additive	0.220	1.171	0.014	0.851	0.238	1.168	0.015	0.839
	Recessive	0.497	1.876	0.020	0.791	0.355	1.880	0.014	0.851
	Dominant	0.072	1.949	0.003	0.970	0.279	1.940	0.011	0.886
rs12255372 [T]	Additive	−0.667	1.150	−0.043	0.563	−0.711	1.157	−0.046	0.540
	Recessive	−0.511	2.208	−0.017	0.817	−0.548	2.202	−0.018	0.804
	Dominant	−1.118	1.673	−0.050	0.505	−1.184	1.682	−0.053	0.483

Each SNP was analyzed for association with the four phenotypes under additive, recessive and dominant genetic models, using linear regression. The basic regression model (A) included adjusting for age, sex and TICV (except of WMH). In addition to the covariates included in model A, the second model (B), was also adjusted for T2D related characteristics, BMI and ancestry. Significant associations are in bold. Abbreviations: SNP- single nucleotide polymorphism; T2D- type 2 diabetes; WMH- white matter hyperintensities.

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Table 5 Association of TCF7L2 SNPs with amygdala, hippocampus, gray matter and white matter hyperintensities (WMH) volume.

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