Table 8 Association of TCF7L2 SNPs with left and right amygdalar volume (recessive genetic model).

TCF7L2 SNPs [T2D risk allele]	Regression model A				Regression model B
	Unstandardized Coefficients		Standardized Coefficients		Unstandardized Coefficients		Standardized Coefficients
	B	Std. Error	β	p value	B	Std. Error	β	p value
Amygdala- Left
rs7901695 [C]	−0.053	0.0180	−0.199	0.003	−0.050	0.018	−0.188	0.005
rs7903146 [T]	−0.052	0.018	−0.196	0.004	−0.049	0.018	−0.185	0.006
rs11196205 [C]	−0.061	0.016	−0.257	0.0001	−0.056	0.016	−0.236	0.0004
rs12255372 [T]	−0.062	0.018	−0.224	0.001	−0.059	0.018	−0.212	0.002
Amygdala- Right
rs7901695 [C]	−0.047	0.0180	−0.183	0.0090	−0.045	0.0180	−0.176	0.0120
rs7903146 [T]	−0.044	0.018	−0.175	0.013	−0.042	0.018	−0.168	0.018
rs11196205 [C]	−0.047	0.016	−0.211	0.003	−0.043	0.016	−0.192	0.006
rs12255372 [T]	−0.044	0.018	−0.167	0.017	−0.042	0.018	−0.158	0.025

The basic linear regression model (A) included adjusting for age, sex and TICV. In addition to the covariates included in model A, the second model (B), was also adjusted for T2D related characteristics, BMI and ancestry. Significant associations are in bold. Abbreviations: SNP- single nucleotide polymorphism; T2D- type 2 diabetes.

Quick links

Search