Table 3 RR of primary glaucoma and POAG incidence by dose from external γ-rays, neutron dose and γ + neutron dose.
From: Glaucoma incidence risk in a cohort of Mayak PA workers occupationally exposed to ionizing radiation
Cumulative dose (Gy), range | Mean cumulative dose (Gy) | Total primary glaucoma | POAG | ||||||
|---|---|---|---|---|---|---|---|---|---|
PYR | Number of cases | RR (95% CI) | p value | PYR | Number of cases | RR (95% CI) | p value | ||
Baseline analysis (5 year lag) a : RR of primary glaucoma and POAG incidence by brain absorbed dose from external γ-rays | |||||||||
0–0.25 | 0.06 | 345,381 | 237 | 1 (reference) | — | 345,512 | 228 | 1 (reference) | — |
0.25–0.5 | 0.36 | 61,697 | 71 | 0.87 (0.65–1.15) | 0.332 | 61,699 | 70 | 0.88 (0.66–1.17) | 0.391 |
0.5–0.75 | 0.62 | 32,775 | 33 | 0.76 (0.50–1.10) | 0.158 | 32,794 | 31 | 0.73 (0.48–1.07) | 0.121 |
0.75–1.0 | 0.87 | 23,771 | 35 | 0.90 (0.59–1.32) | >0.50 | 23,800 | 35 | 0.94 (0.62–1.39) | >0.50 |
1.0–1.25 | 1.12 | 16,275 | 24 | 0.95 (0.58–1.48) | >0.50 | 16,275 | 24 | 0.99 (0.60–1.56) | >0.50 |
1.25–1.5 | 1.37 | 12,744 | 19 | 0.90 (0.51–1.47) | >0.50 | 12,765 | 18 | 0.91 (0.51–1.50) | >0.50 |
1.5–2.0 | 1.72 | 17,407 | 33 | 1.22 (0.80–1.81) | 0.344 | 17,409 | 32 | 1.22 (0.79–1.82) | 0.360 |
≥2.0 | 2.57 | 15,777 | 24 | 0.89 (0.54–1.39) | >0.50 | 15,778 | 23 | 0.87 (0.53–1.38) | >0.50 |
Sensitivity analysis (5 year lag) b : RR of primary glaucoma and POAG incidence by brain absorbed dose from neutrons | |||||||||
0–0.001 | 0.0004 | 50,538 | 57 | 1 (reference) | — | 50,554 | 56 | 1 (reference) | — |
0.001–0.0025 | 0.0016 | 17,990 | 21 | 0.78 (0.41, 1.42) | 0.438 | 17,990 | 21 | 0.83 (0.43, 1.51) | >0.50 |
0.0025–0.005 | 0.0034 | 9,112 | 22 | 1.29 (0.65, 2.51) | 0.462 | 9,130 | 21 | 1.20 (0.60, 2.36) | >0.50 |
0.005–0.01 | 0.0068 | 2,884 | 3 | 0.34 (0.05, 1.23) | 0.158 | 2,884 | 3 | 0.34 (0.05, 1.22) | 0.157 |
≥0.01 | 0.0224 | 1,178 | 3 | 2.06 (0.42, 7.37) | 0.310 | 1,178 | 3 | 2.13 (0.43, 7.73) | 0.292 |
Sensitivity analysis (5 year lag) a : RR of primary glaucoma and POAG incidence by the unweighted sum of brain absorbed γ + neutron dose | |||||||||
0–0.25 | 0.06 | 345,321 | 237 | 1 (reference) | — | 345,441 | 228 | 1 (reference) | — |
0.25–0.5 | 0.36 | 61,694 | 71 | 0.86 (0.65, 1.14) | 0.317 | 61,700 | 70 | 0.88 (0.67, 1.17) | 0.394 |
0.5–0.75 | 0.62 | 32,727 | 33 | 0.74 (0.50, 1.07) | 0.119 | 32,748 | 31 | 0.72 (0.48, 1.04) | 0.099 |
0.75–1.0 | 0.87 | 23,787 | 35 | 0.99 (0.67, 1.41) | >0.50 | 23,817 | 35 | 1.02 (0.69, 1.47) | >0.50 |
1.0–1.25 | 1.12 | 16,343 | 24 | 1.02 (0.64, 1.56) | >0.50 | 16,345 | 24 | 1.06 (0.67, 1.61) | >0.50 |
1.25–1.5 | 1.37 | 12,744 | 19 | 0.99 (0.59, 1.57) | >0.50 | 12,765 | 18 | 0.97 (0.57, 1.56) | >0.50 |
1.5–2.0 | 1.72 | 17,428 | 33 | 1.14 (0.76, 1.67) | >0.50 | 17,430 | 32 | 1.15 (0.75, 1.69) | >0.50 |
≥2.0 | 2.57 | 15,783 | 24 | 0.86 (0.53, 1.34) | >0.50 | 15,786 | 23 | 0.84 (0.51, 1.32) | 0.476 |
