Table 4 Primary glaucoma and POAG incidence risk with external γ-dose, neutron dose and γ + neutron dose.
From: Glaucoma incidence risk in a cohort of Mayak PA workers occupationally exposed to ionizing radiation
Analysis type | Total primary glaucoma | POAG | ||
|---|---|---|---|---|
ERR/Gy (95% CI) | p valuea | ERR/Gy (95% CI) | p valuea | |
Incidence risk associated with brain absorbed dose from external γ-rays i | ||||
Baseline analysisb, 5 year lag | 0.01 (−0.13, 0.19) | >0.50 | 0.0003 (−0.13, 0.19) | >0.50 |
Sensitivity analysis b , in which the first x years following the start of radiation work were assigned to a “zero dose” category when lagging doses by x years | ||||
0 year lag | 0.01 (−0.13, 0.19) | >0.50 | 0.001 (−0.13, 0.19) | >0.50 |
10 year lag | 0.002 (−0.13, 0.19) | >0.50 | −0.003 (−0.14, 0.19) | >0.50 |
15 year lag | −0.001 (−0.13, 0.19) | >0.50 | −0.005 (−0.14, 0.18) | >0.50 |
20 year lag | −0.01 (−0.15, 0.17) | >0.50 | −0.02 (−0.15, 0.17) | >0.50 |
Sensitivity analysis – exclusion stratification, 5 year lag: | ||||
By hypertension | −0.01 (−0.13, 0.17) | >0.50 | −0.01 (−0.14, 0.17) | >0.50 |
By BMI | 0.01 (−0.12, 0.19) | >0.50 | 0.01 (−0.12, 0.20) | >0.50 |
By diabetes mellitus | 0.03 (−0.11, 0.22) | >0.50 | 0.02 (−0.12, 0.21) | >0.50 |
By neutron dose | 0.01 (−0.12, 0.20) | >0.50 | 0.01 (−0.13, 0.19) | >0.50 |
Sensitivity analysis – additional stratification, 5 year lag: | ||||
By smoking index | 0.01 (−0.13, 0.20) | >0.50 | −0.001 (−0.14, 0.20) | >0.50 |
By smoking and alcohol | 0.07 (−0.10, 0.32) | 0.48 | 0.06 (−0.11, 0.30) | >0.50 |
By cataract | −0.04 (−0.16, 0.12) | >0.50 | −0.05 (−0.17, 0.11) | 0.46 |
By cataract surgery | 0.01 (−0.13, 0.20) | >0.50 | 0.004 (−0.13, 0.20) | >0.50 |
Sensitivity analysis b – analysis restricted to workers, 5 year lag: | ||||
Males | −0.05 (−0.19, 0.16) | >0.50 | −0.05 (−0.20, 0.15) | >0.50 |
Females | 0.16 (−0.13, 0.63) | 0.38 | 0.15 (−0.14, 0.63) | 0.42 |
p valuec | 0.27 | 0.28 | ||
Attained age | ||||
<50 years | 3.24 (−2.41, 61.08) | 0.35 | 1.22 (−1.35, 57.68) | >0.50 |
50–59 years | −0.13 (n/a, 0.41) | 0.47 | −0.07 (−0.44, 0.58) | >0.50 |
60–69 years | −0.03 (−0.21, 0.26) | >0.50 | −0.02 (−0.20, 0.28) | >0.50 |
≥70 years | 0.06 (−0.16, 0.41) | >0.50 | 0.02 (−0.20, 0.37) | >0.50 |
p valued | 0.38 | >0.50 | ||
p valuee | 0.49 | >0.50 | ||
Age at first employment | ||||
<30 years | −0.03 (−0.16, 0.18) | >0.50 | −0.03 (−0.17, 0.17) | >0.50 |
30–40 years | −0.19 (n/a, 0.71) | 0.23 | −0.18 (n/a, 0.72) | 0.25 |
≥40 years | 2.98 (−2.31, 26.99) | 0.28 | 1.81 (−1.55, 17.67) | >0.50 |
p valuef | 0.27 | 0.31 | ||
Incidence risk associated with brain absorbed dose from neutrons j | ||||
Sensitivity analysisg, 5 year lag | 22.83 (−33.20, 150.80) | >0.50 | 23.64 (−33.77, 154.10) | >0.50 |
Incidence risk associated with the unweighted sum of brain absorbed γ + neutron dose i | ||||
Sensitivity analysish, 5 year lag | 0.01 (−0.12, 0.19) | >0.50 | −0.01 (−0.14, 0.17) | >0.50 |
