Figure 1 | Scientific Reports

Figure 1

From: Interrogating Mutant Allele Expression via Customized Reference Genomes to Define Influential Cancer Mutations

Figure 1

Developing an unbiased tool to assess the expression of somatic variants. (a) Flowchart of the MAXX pipeline, which ultimately identifies the RNA read count for the mutant allele and the wild type allele. (b) Methodology for mutation expression group placement, represented as V-ex (blue), W-ex (green), and N-ex (red): V-ex, mutations that express the mutant allele; W-ex, mutations that only express the wild type allele; N-ex, mutations that don’t express the wild type allele or the mutant allele. (c) The number of mutations associated with each mutation expression group. These mutations were derived from 19 PDAC patient derived cell lines. (d) The fraction of each mutation expression group for all patient derived cell lines.

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