Figure 5 | Scientific Reports

Figure 5

From: Interrogating Mutant Allele Expression via Customized Reference Genomes to Define Influential Cancer Mutations

Figure 5

Conservation of mutational expression features from cell lines to PDX tumors. (a) Comparison of the DNA allele frequency and RNA allele frequency of each mutation derived from the PDX samples. (b–d) The overlap of V-ex, W-ex, and N-ex mutations between the corresponding cell line and PDX samples. Mutations classified as “discarded” in either the cell line or PDX data were excluded. (e) A two-tailed Wilcoxon Mann Whitney test between the DNA allele frequency of mutations that are present in both the cell line and PDX samples and the DNA allele frequency of mutations that are unique to either the cell line or PDX samples was performed for each mutation expression group.

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