Figure 6
Mutation expression profiles from primary tumors. (a) Comparison of the DNA allele frequency and RNA allele frequency of each mutation derived from the TCGA samples. (b) Correlation of the DNA allele frequency and the RNA allele frequency of CDKN2A, KRAS, SMAD4, and TP53 mutations identified within the TCGA samples. (c) The average first exon methylation of samples that didn’t contain the mutated gene was plotted against the average first exon methylation of samples that did contain the mutated gene. This was performed for non-discarded mutated genes that had available first exon methylation data. (d) A two-sample t-test with a two-tail p-value was performed on the mutant first exon methylation between each mutation expression group.
