Figure 7
Separating mutations by expression enhances PDAC subtyping. (a) The log rank statistic -log10(p-value) based on the NBS results for 75 TCGA samples. The log rank statistic -log10(p-value) was calculated for the NBS results of all pairwise combinations of mutation expression groups from 3–8 number of predefined subtypes. (b) The log rank statistic -log10(p-value) based on the NBS results for 75 TCGA samples using the stratified samples based on results from 2020+, Muffin, OncodriveFM or V-ex and W-ex mutations. (c) Kaplan Meier plot for TCGA samples based on the NBS results using V-ex and W-ex mutations with number of subtypes equal to three. (d) Networks signifying the mutated pathways that are unique to subtype 1 and subtype 2. (e) Cell line drug response data, grouped by identified subtypes and statistical significance via a Wilcoxon Mann Whitney less than test.
