Table 2 Summary of the estimated percentage of seronegative people who became positive for measles or rubella antibodies after vaccination and the estimated vaccination coverage, obtained by fitting to the observed data using maximum likelihood.

From: Estimating the immunogenicity of measles-rubella vaccination administered during a mass campaign in Lao People’s Democratic Republic using multi-valent seroprevalence data

Age group considered in the estimation

Constraint on the vaccine coverage

Estimated % of seronegative people who become positive after vaccination for antibodies to:

Estimated average vaccination coverage (%)

Deviance

Measles (em)

Rubella (er)

5–14 years

>95% (basecase)

83.6 (76,87.9)

95.8 (92.1,98.4)

95 (95,95)

56

 

>90%

83.2 (71.5,89.8)

96.8 (91.4,100)

90 (90,90.7)

50

 

>80%

84.3 (72.9,94.2)

99.9 (92,100)

80.6 (80,90.2)

49

 

>50%

84.7 (74.1,99.9)

99.1 (92.3,100)

81.3 (63.8,89.8)

49

 

>0%

84.7 (73.7,99.9)

99.1 (92.5,100)

81.3 (64,89.4)

49

15–21 years

>95% (basecase)

86.6 (73.1,94.9)

87.4 (66.4,92.1)

95 (95,99.4)

33

 

>90%

88.6 (68.1,96.9)

81.2 (65.2,96.2)

90 (90,99.4)

33

 

>80%

86.9 (61,98.4)

87.3 (61.5,100)

95.2 (80,99.2)

33

 

>50%

84.8 (65.5,99.9)

87.8 (57.9,100)

94 (64.7,99.3)

33

 

>0%

76.7 (64,99.9)

96.2 (60.5,100)

75.6 (65.3,99.3)

33

All age groups

>95% (basecase)

76.8 (67.2,85.2)

92.7 (89.9,95.2)

95 (95,95)

109

 

>90%

75.1 (68.1,81.6)

97.1 (94.3,99.6)

90 (90,90)

94

 

>80%

75.2 (67.8,83.7)

100 (97.5,100)

84.7 (80,88.2)

90

 

>50%

75.2 (68.3,99.9)

100 (97.3,100)

84.7 (63,88.2)

90

 

>0%

75.2 (68.3,99.8)

100 (97.4,100)

84.7 (63.9,88.2)

90

  1. The values in parentheses show the 95% confidence intervals, based on 1000 bootstraps. The number of degrees of freedom when considering data for 5–14, 15–21 and 5–21 year olds was 23, 14, and 14 respectively.