Figure 3
Testing of HER2 recycling model. (A) Schematic representation of the recycling model. The Affibody binding process is not shown. The processes represented in grey color were found negligible and removed for the final fitting results. (B) Experimental data points and trajectories of the final fit of the recycling model, normalized by dividing by the scaling constant sc. (C) Fluxes with relevant contributions in the final fit of the recycling model for the condition with 60 min trastuzumab treatment, normalized by sc. The sign of the flux was chosen such that the backward processes (disassociation and recycling) are negative while all other processes give positive fluxes.
