Figure 1
From: Evidence of CD40L/CD40 pathway involvement in experimental transfusion-related acute lung injury
Evaluation of TRALI development. Survival curves (A - n = 4) and rectal temperatures (B - n = 10) were measured for each experimental group. The general appearance of the lungs (C) is represented for each group of mice. Wet lung to body weight ratio (D) and BAL total protein concentration (E) were measured for each group of mice. Lung microarchitecture is presented after H&E staining (F) for each group of mice (Original magnification x400). Scale bar, 50 μm. Pulmonary cellular exudate area was measured in ratio to the microscopic field. (G) Data are presented as means ± SEM. *p < 0.05, **p < 0.01, and ***p < 0.001 indicate differences between the [LPS] (n = 4) and [LPS + anti-MHC I] (n = 10) groups; †p < 0.05, ††p < 0.01, and †††p < 0.001 indicate differences between the [LPS] and [LPS + anti-MHC I + anti-CD40L] (n = 10) groups; and #p < 0.05, ##p < 0.01, and ###p < 0.001 indicate differences between the [LPS + anti-MHC I] and [LPS + anti-MHC I + anti-CD40L] groups. (A) Except for condition LPS + antiMHC1, the values of the other conditions are confused for 100% of percent survival.
