Table 5 ANOVA for CCD results of uricase production by Aspergillus welwitschiae.

From: Mathematical modeling for bioprocess optimization of a protein drug, uricase, production by Aspergillus welwitschiae strain 1–4

Source

Sum of Squares

df

Mean Square

F-value

P-value Prob >F

Model

1633.99

9

181.55

35.92

<0.0001

X1 - (incubation time)

121.05

1

121.05

23.95

0.0006

X2 - (inoculum size)

13.24

1

13.24

2.62

0.1366

X3 - (yeast extract)

77.16

1

77.16

15.27

0.0029

X1 X2

0.03

1

0.03

0.01

0.9413

X1 X3

19.59

1

19.59

3.88

0.0773

X2 X3

25.85

1

25.85

5.11

0.0473

X12

80.21

1

80.21

15.87

0.0026

X22

680.98

1

680.98

134.72

<0.0001

X32

814.05

1

814.05

161.05

<0.0001

Residual

50.55

10

5.05

  

Lack of Fit

38.22

5

7.64

3.10

0.1199

Pure Error

12.33

5

2.47

  

Cor Total

1684.53

19

   

PRESS

318.46

Adeq Precision

15.8864

Std. Dev.

2.25

R 2

0.9700

C.V.%

4.82

Pred R 2

0.8110

Mean

46.64

Adj R 2

0.9430