Table 7 Fit summary for experimental results of CCD for optimization of uricase production by Aspergillus welwitschiae.

From: Mathematical modeling for bioprocess optimization of a protein drug, uricase, production by Aspergillus welwitschiae strain 1–4

Model Summary Statistics

Source

SD

R2

Adjusted R2

Predicted R2

PRESS

Linear

9.60

0.1255

−0.0384

−0.2648

2130.67

2FI

10.48

0.1525

−0.2386

−1.1963

3699.77

Quadratic

2.25

0.9700

0.9430

0.8110

318.46

Lack of Fit Tests

Source

SS

Df

MS

F- value

P- value

Linear

1460.75

11

132.80

53.87

0.0002

2FI

1415.28

8

176.91

71.76

<0.0001

Quadratic

38.22

5

7.64

3.10

0.1199

Pure Error

12.33

5

2.47

  

Sequential Model Sum of Squares

Linear vs Mean

211.46

3

70.49

0.77

0.5298

2FI vs Linear

45.47

3

15.16

0.14

0.9355

Quadratic vs 2FI

1377.06

3

459.02

90.81

<0.0001

Residual

14.53

6

2.42

  
  1. “*Significant values, df: degree of freedom, PRESS: sum of squares of prediction error, 2FI: two factors interaction, SD: Standard deviation, SS: Sum of Squares, MS: Mean Square”.
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