Figure 7
Minimal phenotypic modification by AOX, of Cox10 heart knockout. (A,B) Survival curves of mice of the indicated genotypes: Cox10−/− – cardiomyocyte-specific knockout of Cox10, i.e. mice were Cox10fl/fl plus Myh6-cre+/−; Cox10−/− + cardio AOX – cardiomyocyte-specific knockout of Cox10 plus activation of SNAPf-AOX by Myh6-cre (both heterozygous); Myh6-cre – Myh6-cre+/− only, no cre – control mice lacking Myh6-cre, cardio AOX – cardiomyocyte-specific activation of SNAPf-AOX by Myh6-cre, both hemizygous; Cox10+/− – cardiomyocyte-specific heterozygous knockout of Cox10, i.e. mice were Cox10+/fl and Myh6-cre+/−; Cox10+/− + cardio AOX – cardiomyocyte-specific heterozygous knockout of Cox10, i.e. mice were Cox10+/fl and heterozygous for both Myh6-cre and SNAPf-AOX. n ≥ 6 for all groups. (C) Cardiac ejection fraction (EF, %) computed for individual mice of the indicated genotypes and ages, means ± SD, by echocardiography. Horizontal lines marked with asterisks indicate significant differences (one-way ANOVA within an age point, applying Tukey’s post hoc HSD test; *, **, ***p < 0.05, 0.01, 0.001, respectively).
