Figure 5
From: Role of POMC and AgRP neuronal activities on glycaemia in mice
Stimulation of POMC neurons in diabetic ob/ob mice does not influence blood glucose levels. Food intake (daily (a) and acute (c)), blood glucose (daily (b) and acute (d)), body weight (e) and ITT (f) of diabetic ob/ob; POMC-cre male mice. (g) Representative m-Cherry expression image for the verification of the injection site. Data are shown as means ± s.e.m. (n = 3–5/group). Statistics were performed as described in Fig. 1. Area above the curve (AAC) was evaluated with 1-way ANCOVA. AAV8-DIO-hM3Dq-mCherry (activator) was injected into the study and control mice that received CNO and PBS, respectively for 5 days. All mice then received PBS for an additional 5 days. CNO (2.5 mg/kg) was injected every 6 hours. Abbreviations are the same as described in Fig. 1. The image in (g) was captured at 20× magnification. Scale bar, 120 μm. NS: Not significant.
