Figure 6
From: Role of POMC and AgRP neuronal activities on glycaemia in mice
Regulation of AgRP and POMC neurons by DREADD: Pair-feeding studies. Daily (a) and acute (c) blood glucose and body weight (e) of normoglycaemic AgRP-ires-cre male mice. Daily (b) and acute (d) blood glucose and body weight (f) of normoglycaemic POMC-cre male mice. Data are shown as means ± s.e.m. (n = 4–10/group). AAV8-DIO-hM3Dq-mCherry (activator) and AAV8-DIO-hM4Di-mCherry (inhibitory) were injected into the arcuate nucleus of AgRP-ires-cre and POMC-cre mice, respectively. CNO (1–2.5 mg/kg) or PBS was injected every 6 or 8 hours for 5 days. All mice then received PBS for an additional 3 days. All experiments were done under pair-feeding conditions. Abbreviations are the same as described in Fig. 1. Statistics were performed as described in Fig. 1.
