Figure 1

The overlapped DEGs were associated with AI-resistance in ER-positive breast cancer. (A) The DEGs of GSE87411 dataset were shown as cluster heatmaps. The DEGs were generated from T-group (untreated samples versus post-treated samples with AIs) and R-group (post-treated samples sensitive versus resistant to AIs). The red points represented upregulated genes (logFC>1), while the green points represented downregulated genes (logFC<−1). The criteria of P value < 0.05 was considered to be significantly different. DEGs, differentially expressed genes; AI, aromatase inhibitor; FC, fold change. (B) The volcano plots showed DEGs in T-group and R-group. In T-group, 82 genes were discovered to be downregulated after AI-treatment (T-down), while none was identified to be upregulated. In R-group, 48 DEGs were obtained. Among them, 6 downregulated genes (R-down) and 42 upregulated genes (R-up) were identified. The red points represented upregulated genes, while the green points represented downregulated genes. The DEGs were screened out with the criteria of P value < 0.05 and |log fold change (FC)| >1. Down, downregulated genes; Up, upregulated genes. (C) The Venn diagram demonstrated different overlaps of genes among 5 groups: T-group, R-group, T-down, R-up and R-down. 30 overlapped DEGs was found to be significantly downregulated after neoadjuvant AI-treatment (T-down), and highly upregulated in AI-resistant samples compared with AI-sensitive samples (R-up). T-down, downregulated genes of T-group; R-up, upregulated genes of R-group; R-down, downregulated genes of R-group.