Figure 3 | Scientific Reports

Figure 3

From: Pioglitazone treatment prior to transplantation improves the efficacy of human mesenchymal stem cells after traumatic brain injury in rats

Figure 3

Combination treatment significantly decreases the expression of inflammatory chemokines CCL20 and IL1-β in the rat brain cortex 35 days after TBI. (A) Representative images of immunoperoxidase staining of cortex (adjacent to the injury site) showing the CCL20 or IL1-β immunoreactivity under different experimental conditions. Scale bar 100 µ. (B,C) Histograms showing the numbers (mean ± SEM) of CCL20 (B) or IL1 β (C) positive cells in the cortex. PG, pioglitazone, hMSC, human mesenchymal stem cells, combo., PG + hMSC combination treatment. Numbers in parentheses indicate the number of animals in each group. *p < 0.01, **p < 0.001.

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