Figure 4 | Scientific Reports

Figure 4

From: Pioglitazone treatment prior to transplantation improves the efficacy of human mesenchymal stem cells after traumatic brain injury in rats

Figure 4

PG-hMSC combination treatment improves neurogenesis and increases BDNF level after TBI. (A) Representative immunofluorescence images showing DCX immunoreactivity in the SVZ (Scale bar 100 µ) or DG region (Scale bar 200 µ) under different experimental conditions. (B) Histogram showing DCX immunoreactivity (Mean ± SEM) in SVZ (B) or DG (C) under different experimental conditions measured using image J. (D) Histogram showing serum BDNF level measured by ELISA. IntDen, integrated density, PG, pioglitazone, hMSC, human mesenchymal stem cells, SVZ, subventricular zone, LV, lateral ventricle, DG, dentate gyrus. Numbers in parentheses indicate the number of animals in each group. *p < 0.01, **p < 0.001.

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