Figure 1
Effects of Ptch1+/− heterozygosity on cutaneous metabolic landscape. (A) Clustering analysis of the abundance of named metabolites in the skin of Ptch1+/+/ODCt/C57BL/6 and Ptch1+/−/ODCt/C57BL/6 mice. Metabolites that were not significantly changed were not included in this analysis. Each row represents a single metabolite while each column represents an independent skin sample. The color scale indicates relative level of the abundance of each metabolite with red indicating levels greater than mean and blue indicating levels below the mean. (B) Pie chart showing numbers of biochemicals, which are increased or decreased in the skin; (C) Graph showing principle component analysis of global metabolomics data. (D) Graph showing the data of pathway set enrichment analysis (PSEA). Pathways containing greater than three identified metabolites are included in the analysis. The intensity of red color is associated with the PSEA score of each metabolite. PSEA score greater than one suggests the indicated pathway have above average number of metabolites that are significantly altered.
