Table 3 Levels of NAD, NGD and NHD in Nmnat3 KO mice.

From: Metabolism and biochemical properties of nicotinamide adenine dinucleotide (NAD) analogs, nicotinamide guanine dinucleotide (NGD) and nicotinamide hypoxanthine dinucleotide (NHD)

  

WT

Nmnat3 KO

 

NAD (nmol/g tissue)

Heart

120 ± 10

98 ± 15

NS

Liver

120 ± 40

130 ± 20

NS

Muscle

190 ± 20

170 ± 20

NS

Cerebrum

41 ± 12

58 ± 23

NS

NGD (nmol/g tissue)

Heart

2.2 ± 0.5

0.86 ± 0.13

p < 0.05

Liver

1.5 ± 0.1

1.5 ± 0.2

NS

Muscle

0.80 ± 0.12

0.59 ± 0.11

p < 0.05

Cerebrum

0.66 ± 0.09

0.66 ± 0.11

NS

NHD (nmol/g tissue)

Heart

0.54 ± 0.03

0.83 ± 0.22

NS

Liver

0.19 ± 0.05

0.18 ± 0.05

NS

Muscle

0.21 ± 0.06

0.18 ± 0.04

NS

Cerebrum

0.21 ± 0.04

0.21 ± 0.04

NS

  1. Levels of NAD analogs in tissue samples prepared from 3-month-old Nmnat3 KO and WT mice were measured by orbitrap. Data are presented as means ± SD (n = 4). NS means not significant.
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