Table 4 Levels of NAD, NGD and NHD in CD38 KO mice.

From: Metabolism and biochemical properties of nicotinamide adenine dinucleotide (NAD) analogs, nicotinamide guanine dinucleotide (NGD) and nicotinamide hypoxanthine dinucleotide (NHD)

  

WT

CD38 KO

 

NAD (nmol/g tissue)

Heart

160 ± 20

460 ± 10

p < 0.05

Liver

120 ± 40

450 ± 20

p < 0.05

Muscle

190 ± 4

320 ± 30

p < 0.05

NGD (nmol/g tissue)

Heart

1.2 ± 0.1

1.8 ± 0.1

p < 0.05

Liver

1.3 ± 0.3

1.6 ± 0.3

NS

Muscle

0.74 ± 0.15

0.52 ± 0.09

p < 0.05

NHD (nmol/g tissue)

Heart

0.53 ± 0.15

0.61 ± 0.16

NS

Liver

0.23 ± 0.16

0.23 ± 0.11

NS

Muscle

0.16 ± 0.06

0.035 ± 0.04

p < 0.05

  1. Levels of NAD analogs in tissue samples prepared from 3-month-old WT and CD38 KO mice were measured by orbitrap. Data are presented as means ± SD (n = 4). NS means not significant.
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