Figure 3 | Scientific Reports

Figure 3

From: Prothrombin, alone or in complex concentrates or plasma, reduces bleeding in a mouse model of blood exchange-induced coagulopathy

Figure 3

Blood losses following tail transection (TT) and treatment with 4F-VKDP or 3F-VKDP. Panel (A), blood loss in µl following tail transection (TT) and treatment with 12 ml/kg body weight of vehicle (Vehicle, grey bar), PCC (hatched bar) or 4F-VKDP (black bars) containing the dose in IU/kg specified below the bars. Values are presented as mean ± SD, n = 15 mice per group; *p < 0.05, **p < 0.01, ***p < 0.001 versus groups linked by horizontal capped lines by ANOVA with post-tests. Panel (B), as in Panel A, except that mice were treated with vehicle or 36 IU/kg 4F-VKDP (white bar) or 36 IU/kg 3F-VKDP identified by the factor they lacked (black bars, e.g. “No FVII” contained prothrombin, FIX, and FX) below the axis.

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