Table 3 Multivariable proportional hazard regression model on overall survival.

Cohort

<0.001

Hyponatremia vs Control

1.66

1.38–2.01

Age (years)

<0.001

71 vs 53^a

1.36

1.20–1.55

ECOG PS

<0.001

1 vs 0

1.31

1.06–1.61

<0.01

2 vs 0

1.8

1.32–2.44

<0.001

3 vs 0

2.91

2.16–3.90

<0.001

4 vs 0

8.62

4.40–16.88

0.001

Histology

<0.001

NSCLC vs CRC

1.4

1.05–1.88

0.02

BC vs CRC

0.85

0.64–1.14

0.3

GEC vs CRC

1.75

1.27–2.39

<0.001

Melanoma vs CRC

1.52

1.04–2.22

0.03

PaC vs CRC

2.42

1.65–3.55

<0.001

BTC vs CRC

2.69

1.82–3.99

<0.001

RCC vs CRC

0.3

0.16–0.56

0.001

SCLC vs CRC

1.61

1.02–2.53

0.04

NET vs CRC

0.97

0.56–1.66

0.9

PC vs CRC

0.67

0.36–1.23

0.2

Other vs CRC

1.08

0.79–1.47

0.6

Liver metastases

<0.001

Yes vs No

1.7

1.43–2.02

Bone metastases

<0.001

Yes vs No

1.39

1.16–1.67

Brain metastases

<0.001

Yes vs No

1.74

1.32–2.28

Previous lines of treatment (N)

<0.001

1–2 vs 0

1.39

1.16–1.67

<0.001

>2 vs 0

1.59

1.26–2.02

<0.001

Days of hospitalization

0.005

9 vs 3^a

1.13

1.04–1.23

Other electrolyte imbalances

 0.04

Calcium vs None

1.32

1.03–1.68

0.03

Potassium vs None

0.87

0.66–1.14

0.3

Both vs None

1.25

0.91–1.71

0.2

Harrell c-index

Apparent: 0.75

Bias-corrected: 0.74