Table 1 Mutation profile of the most frequently altered genes in our study population by microsatellite instability status and tumor site.
From: Mutation profiling of cancer drivers in Brazilian colorectal cancer
Microsatellite Instability | Tumor Site | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
MSI negative (N = 78) | MSI positive (N = 12) | P value | Proximal Colon (N = 20) | Distal Colon (N = 71) | P value | |||||
n | (%) | n | (%) | n | (%) | n | (%) | |||
APC | 59 | (75.6) | 5 | (41.7) | 0.034** | 10 | (50.0) | 55 | (77.5) | 0.025* |
TP53 | 51 | (65.4) | 1 | (8.3) | <0.001* | 4 | (20.0) | 48 | (67.6) | <0.001* |
KRAS | 45 | (57.7) | 3 | (25.0) | 0.059* | 3 | (15.0) | 45 | (63.4) | <0.001* |
PIK3CA | 12 | (15.4) | 2 | (16.7) | 0.999** | 4 | (20.0) | 10 | (14.1) | 0.499** |
FBXW7 | 8 | (10.3) | 2 | (16.7) | 0.617** | 2 | (10.0) | 8 | (11.3) | 0.999** |
NF1 | 5 | (6.4) | 3 | (25.0) | 0.070** | 3 | (15.0) | 5 | (7.0) | 0.367** |
TGFBR2 | 0 | (0.0) | 8 | (66.7) | <0.001** | 6 | (30.0) | 2 | (2.8) | 0.001** |
ATM | 3 | (3.8) | 3 | (25.0) | 0.029** | 4 | (20.0) | 2 | (2.8) | 0.020** |
BRAF | 3 | (3.8) | 5 | (41.7) | 0.001** | 8 | (40.0) | 0 | (0.0) | <0.001** |
BLM | 1 | (1.3) | 6 | (50.0) | <0.001** | 5 | (25.0) | 2 | (2.8) | 0.005** |
MSH6 | 0 | (0.0) | 4 | (33.3) | <0.001** | 2 | (10.0) | 2 | (2.8) | 0.209** |
NOTCH1 | 1 | (1.3) | 2 | (16.7) | 0.046** | 1 | (5.0) | 2 | (2.8) | 0.530** |
NRAS | 4 | (5.1) | 0 | (0.0) | 0.999** | 0 | (0.0) | 4 | (5.6) | 0.572** |
PTEN | 2 | (2.6) | 2 | (16.7) | 0.084** | 3 | (15.0) | 1 | (1.4) | 0.032** |
CHEK2 | 1 | (1.3) | 2 | (16.7) | 0.046** | 1 | (5.0) | 2 | (2.8) | 0.530** |
ERBB3 | 3 | (3.8) | 0 | (0.0) | 0.999** | 0 | (0.0) | 3 | (4.2) | 0.999** |
ERBB4 | 3 | (3.8) | 0 | (0.0) | 0.999** | 1 | (5.0) | 2 | (2.8) | 0.530** |
NOTCH2 | 0 | (0.0) | 3 | (25.0) | 0.002** | 2 | (10.0) | 1 | (1.4) | 0.120** |
ROS1 | 1 | (1.3) | 2 | (16.7) | 0.046** | 2 | (10.0) | 1 | (1.4) | 0.120** |
STAT5B | 0 | (0.0) | 3 | (25.0) | 0.002** | 2 | (10.0) | 1 | (1.4) | 0.120** |
