Figure 5 | Scientific Reports

Figure 5

From: CXCL16 positively correlated with M2-macrophage infiltration, enhanced angiogenesis, and poor prognosis in thyroid cancer

Figure 5

Blocking CXCL16 using anti-CXCL16 antibody (aCXCL16) reduced tumor growth of PTCs in a xenograft mouse model. BHP10-3SCp cells were co-transplanted with macrophages in nude mice, and aCXCL16 or anti-IgG (control) were injected intraperitoneally. (A) Comparing tumor growth between aCXCL16 and control groups; (B) Immunohistochemical staining for ERG, F4/80, and Ki-67 and TUNEL assay were performed in xenograft tumors. Representative images (magnification, x400) and percentage of ERG+, F4/80+, Ki-67+, and TUNEL+ cells. *P < 0.05 compared with control group.

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