Figure 2
From: Pharmacological inhibition of Notch signaling regresses pre-established abdominal aortic aneurysm
Notch inhibition restores the structural integrity of aorta. (A) Representative images showing changes in maximal external aortic diameter (MEAD) of suprarenal aorta in the various experimental groups. (B) Quantification of MEAD of suprarenal aorta (mm) as measured by microscopy (n = 16–18). (C) Aneurysm severity (type I to IV) scored using a classification system and analyzed by Fisher exact test. (D) Representative histological images showing H&E staining in the experimental groups at 56 days of DAPT treatment. (E,F) Representative immunohistochemistry (IHC) images of aorta showing elastin and tropoelastin staining in the indicated groups. (G,H) Quantification of elastin fragmentation scores and tropoelastin expression (n = 6). Tukey multiple comparisons test was used for data analysis in (G-H). *P < 0.05; ***P < 0.001; ns = non-significant. Scale bar = 1mm in A and 50 µm in (D–F).
