Figure 5 | Scientific Reports

Figure 5

From: Controlling Obesity and Metabolic Diseases by Hydrodynamic Delivery of a Fusion Gene of Exendin-4 and α1 Antitrypsin

Figure 5The alternative text for this image may have been generated using AI.

Effects of EAT gene transfer on transgenic ob/ob mice. (A) Body weight change. (B) Representative images of mice at the end of the experiment. (C) Body composition. (D) Food intake. (E) Representative images of H&E staining of WAT sections. Arrows point to crown-like structures. (F) Adipocyte size distribution. (G) Expression levels of key genes responsible for chronic inflammation in WAT. (H) Profiles of blood glucose concentration as function of time upon intraperitoneal injection of glucose. (I) Profiles of glucose concentration (percentage of initial value) as a function of time upon intraperitoneal injection of insulin. (J) Representative images of H&E staining of the pancreatic islets; Scale bar = 50 μm. Values in (A,C,D) and (F–I) represent average ± SD (n = 5). *P < 0.05 compared with the control; **P < 0.01 compared with the control.

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