Table 4 Change in volume of renal AML following everolimus treatment.

From: Mutational analysis of renal angiomyolipoma associated with tuberous sclerosis complex and the outcome of short-term everolimus therapy

Mean ± SD/Range

Classification

4 weeks (%)

P value

12 weeks (%)

P value

All

N = 30

36.51 ± 23.94 (4.23–84.87)

1.57E-11#*

56.47 ± 23.32 (4.88–97.36)

3.25E-19#*

Age

≤35 years (n = 17)

32.87 ± 24.85 (4.23–84.49)

0.25

51.80 ± 26.12 (4.88–97.36)

0.26

>35 years (n = 13)

41.28 ± 22.76 (8.10–84.87)

62.58 ± 18.24 (37.46–90.71)

Sex

Male (n = 11)

38.38 ± 119.58 (8.34–74.99)

0.75

68.55 ± 11.68 (54.48–90.71)

0.03*

Female (n = 19)

35.43 ± 26.59 (4.23–84.87)

49.47 ± 25.67 (4.88–97.36)

Primitive Volume

<200 cm3 (n = 18)

39.53 ± 22.69 (8.10–84.87)

0.41

64.70 ± 16.79 (34.72–90.71)

0.02*

≥200 cm3 (n = 12)

31.99 ± 26.04 (4.23–84.49)

44.12 ± 26.84 (4.88–97.36)

Mutation

With Mutation (n = 5)

28.95 ± 19.77 (6.93–51.04)

0.51

44.13 ± 25.03 (15.92–77.64)

0.43

No Mutation (n = 14)

37.05 ± 23.79 (7.87–84.87)

54.25 ± 23.88 (4.88–90.05)

  1. #Means comparison with baseline.
  2. *Means P < 0.05 and the difference is statistically significant.