Table 1 Estimates of evolutionary divergence over sequence pairs between genotypes/sub-genotypes.

From: Emerging recombination of the C2 sub-genotype of HFMD-associated CV-A4 is persistently and extensively circulating in China

Genotype

Evolutionary Divergence

A

B

D

C1

C2

C3

C4

C5

A

/

6.55%

17.59%

8.79%

8.17%

8.74%

9.07%

9.05%

B

15.19%

/

16.90%

9.74%

9.14%

10.57%

9.24%

9.14%

D

25.14%

26.45%

/

16.12%

16.50%

17.70%

17.07%

16.72%

C1

16.28%

17.60%

24.92%

8.69%

5.78%

7.01%

7.77%

7.18%

C2

15.21%

17.58%

25.50%

11.54%

5.42%

7.91%

8.48%

7.61%

C3

14.79%

17.74%

26.01%

13.88%

13.82%

7.07%

6.92%

7.07%

C4

15.65%

17.99%

24.19%

14.40%

14.88%

12.96%

7.07%

6.87%

C5

15.41%

17.79%

24.84%

15.22%

15.40%

14.57%

14.87%

6.12%

  1. Note: The lower-left data are nucleotide diversity. The upper-right data in italic are deduced amino acid sequence diversity. The mean nucleotide diversities within genotypes/sub-genotypes (this study) are marked with an underline in bold.
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