Table 1 Characteristics of the MCC-Spain study participants and association of every risk factor with CRC.

Characteristic	Controls (n = 2744)		CRC cases (n = 1336)		Crude OR^a	95% CI	P-value	Adjusted OR^b	95% CI	P-value
Characteristic	n	%	n	%	Crude OR^a	95% CI	P-value	Adjusted OR^b	95% CI	P-value
Age (years) at index date, median (IQR)	65	(56–72)	68	(60–76)
Male sex	1469	53.5	865	64.8
Family history of CRC	333	12.1	292	21.9	2.29	1.90–2.75	<0.0001	2.31	1.91–2.78	<0.0001
Cigarette smoking history	1549	56.5	779	58.3	1.20	1.04–1.38	0.01	1.07	0.93–1.24	0.34
High risk consumption alcohol	427	15.6	300	22.5	1.38	1.16–1.63	0.0002	1.31	1.10–1.56	0.0027
Diabetes mellitus	400	14.6	234	10.6	1.02	0.85–1.23	0.84	1.07	0.85–1.34	0.56
Arterial hypertension	1055	38.5	562	42.1	0.95	0.82–1.09	0.43	0.94	0.82–1.09	0.44
High waist–hip ratio^c	1875	68.3	1082	81.0	1.34	1.13–1.59	0.0007	1.30	1.09–1.54	0.0032
Obesity (BMI ≥30 kg/m²)	188	6.9	142	10.6	1.36	1.07–1.73	0.01	1.29	1.04–1.64	0.043
Physical activity in leisure time	1057	38.5	619	46.3	0.73	0.63–0.84	<0.0001	0.74	0.65–0.80	0.0001
High intake of vegetables (>200 g/day)	846	30.8	345	25.8	0.72	0.62–0.84	<0.0001	0.75	0.64–0.88	0.0004
High intake of red meat (>65 g/day)	1123	40.9	674	50.5	1.38	1.20–1.59	<0.0001	1.30	1.13–1.50	0.0002
Regular ASA users	327	11.9	150	11.2	0.78	0.63–0.97	0.02	0.73	0.59–0.91	0.0060
Regular NSAIDs non-ASA users	422	15.4	122	9.1	0.56	0.45–0.69	<0.0001	0.59	0.47–0.74	<0.0001
Regular statin users	535	19.6	250	18.7	0.81	0.68–0.96	0.02	0.84	0.70–1.01	0.060

ASA: acetylsalicylic acid; BMI: body mass index; MET: Metabolic equivalent of task (MET) per hour per week; NSAID: Nonsteroidal Anti-inflammatory Drugs.
^aORs and 95% CI derived from logistic regression models adjusted for the study design factors (age, sex, center and education).
^bEach variable adjusted for the study design adjustment and potential confounders for statin use (alcohol, waist-hip ratio, physical activity, read meat and ASA or NSAIDs).
^c≥ 0.90 cm (men); ≥0.85 cm (women).

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