Table 1 Cellular processes affected by the deregulated genes induced by HPV E1 proteins. p-value ≤ 0.05.

Regulation of peptidyl-tyrosine phosfhorylation

27.78%**

Endothelial cell chemotaxis

29.95%**

Regulation of MHC class I biosynthetic process

31.82%**

Formation of primary germ layer

16.67%**

Negative regulation of viral genome replication

18.42%**

Melanosome localization

27.73%**

Cellular response to vascular endothelial growth factor stimulus

16.67**

Negative regulation of viral genome transcription

15.79%**

MDA-5 signaling pathway

13.64%**

Negative regulation of viral genome replication

16.67**

Positive regulation of epidermal cell differentiation

13.16%**

Regulation of natural killer cell chemotaxis

11.36%*

Defense response to virus

5.56%**

Regulation of toll-like receptor 9 signaling pathway

7.89%**

Viral genome replication

11.36%**

Cellular response to interferon-gamma

5.56%**

Monocyte differentation

5.26%**

Type I interferon signaling pathway

4.55%**

Cytokine-mediated signaling pathway

5.56%**

MDA-5 signaling pathway

5.26%**

Pharyngeal system development

2.27%*

Regulation of bone mineralization

5.56%**

Cellular response to corticotropin-releasing hormone stimulus

2.63%**

Bile acid and bile salt transport 2.27%*

2.27%*

Response to corticosterone

2.63%**