Figure 5

Modulation of DOI-induced HTR by mGluR2/3. (A) Effect of the mGluR2/3 antagonist LY341495 (3 mg/kg, i.p.) on DOI (1 mg/kg, i.p.)-induced HTR (n = 14); (B) quantification of total HTR count for the 90 min following administration of the DOI. (C) Effect of vehicle (n = 11) and different doses of mGluR2/3 agonist LY404039 (5 mg/kg (n = 11) and 10 mg/kg (n = 5) on DOI (1 mg/kg, i.p.); quantification of total HTR count between 0–30 min (D) and 60–90 min (E) after the administration of DOI. Two-tailed Student’s t-test (B), one-way ANOVA with Bonferroni’s post hoc test (D,E). Values represent mean ± S.E.M. (*P < 0.05, ***P < 0.001). Arrow indicates time of administration of DOI.