Figure 3

Calcium imaging and insulin assessment of islets: (a) Results of calcium imaging during 2 low-high glucose challenges and representative confocal images of the peak calcium response to glucose challenges; and (b) the insulin content within control (i.e. non-pFUS treated islets) and islets treated with pFUS at low, medium and high intensities and (c) the amount of insulin released from control (i.e. non-pFUS treated islets) and islets treated with pFUS at low, medium and high intensities. ^aP < 0.05: control vs. low or medium or high dose; ^bP < 0.05: low vs. medium or high dose; ^cP < 0.05: medium vs. high dose; *P < 0.05: low vs. high glucose (Two (a) or one (b,c)-way ANOVA post-hoc Tukey Test).