Figure 3
From: Cold exposure induces dynamic, heterogeneous alterations in human brown adipose tissue lipid content
Conceptual model illustrating the calculation of normalized cooling dose, a construct we created to standardize reporting of personalized cooling protocols. Simulated water temperature (°C) vs. time (min) plots were created to compare two protocols of equal duration that begin (32 °C) and end (10 °C) at the same temperatures but follow linear (solid line) or step (dashed line) cooling gradient profiles (a). To calculate normalized cooling dose, the following steps are completed: (1) relative water temperatures (°C) are expressed as the change (Δ) in temperature from the starting or thermoneutral temperature (b), (2) cooling dose (°C*min) is calculated from the area under the relative water temperature curve (c), and (3) normalized cooling dose (°C*min*m−2) is found by dividing cooling dose by body surface area to account for differences in participant body size (d).
