Figure 1

Peripheral alteration of immune cells seemed to be occurred from bone marrow in EBV infected mice. (A)Schematic view of a process of the analysis. For the reconstitution of human hematopoiesis in NOG mice, 1 × 10⁴ human CD34⁺ cord blood cells were transplanted into NOG mice after irradiation (2.0 Gy). EBV injection was performed after confirming the engraftment of human leukocytes in mice. Hematopoietic analysis was performed after beginning dramatically weight loss. Uninfected mice were utilized as controls. (B,C) Comparison of human Monocyte between infected (n = 4) and uninfected (n = 7) humanized mice in PB. hCD14⁺ monocytes significantly increased in EBV infected mice. hCD14⁺ were detected from hCD45⁺ population. **p < 0.05.