Table 4 Heritability estimates for CMR and ECG LV phenotypes.

From: Marked variation in heritability estimates of left ventricular mass depending on modality of measurement

 

phenotype

number of phenotyped individuals

QTDT

GCTA-GREML

h2QTDT (%)

SE (%)

P-value

no. genotyped

h2IBS>0.05 (%)

SE (%)

P-value

CMR

LVM

397

17

9

0.0469

362

27

12

0.0230

LVM index

397

17

8

0.0402

362

27

12

0.0196

LV end-diastolic volume

405

41

10

3.5E-05

369

47

12

7.2E-05

LV end-diastolic volume index

405

42

10

1.7E-05

369

47

12

5.9E-05

LV end-systolic volume*

397

32

10

0.0012

362

33

12

0.0049

LV end-systolic volume index*

397

35

10

0.0004

362

36

12

0.0019

ECG

Cornell voltage

404

25

9

7.4E-03

364

21

11

0.0541

Cornell duration

404

29

9

8.8E-04

364

26

11

0.0129

LVM†

404

62

9

3.5E-11

364

60

10

8.5E-09

LVM‡

362

42

16

0.0087

330

43

11

2.2E-06

Sokolow-Lyon voltage

404

35

9

0.0001

364

40

11

 0.0003

Sokolw-Lyon duration

403

57

9

9.7E-10

363

60

10

 8.2E-0.9

  1. LV, left ventricular. †LVM adjusted for significant (P-value < 0.01) covariation in height, treatment-adjusted SBP and DBP and sex, ‡LVM adjusted for significant (P-value < 0.01) covariation in CMR chest lateral diameter, height and treatment-adjusted SBP. *GCTA-GREML models were fitted without “–no-constrain” flag.
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