Table 1 Stability of NP-59 in mouse plasma, mouse bile, mouse liver, and human liver S9 fractions.

From: Imaging of hepatic drug transporters with [131I]6-β-iodomethyl-19-norcholesterol

Time (min)

Mouse plasma

Mouse bile

Mouse liver

Human liver S9

10

95.4 ± 2.5

95.0 ± 3.8

95.1 ± 3.6

95.0 ± 4.3

30

94.8 ± 3.2

94.2 ± 4.2

93.5 ± 4.5

94.4 ± 2.1

60

93.9 ± 3.6

93.3 ± 3.5

92.8 ± 3.3

93.3 ± 3.2

  1. The fractional ratios of NP-59 (non-metabolite) were calculated by dividing the radioactive counts for each fraction by the total radioactivity count.
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