Figure 3
(a) Autoradiography studies of brain slices collected at 15 min, 1 h and 6 h after intravenous administration of [131I]TTR at different Bregma values. The contour of the brain is delineated in all cases for clarity; (b) Picture of a representative slice corresponding to Bregma = −0.94 mm. The cortex (red), hippocampus (green), striatum (yellow) and third ventricles (dark blue) are delineated; three consecutive slices containing the regions mentioned above were analyzed per animal and time point, and the results are represented as concentration of radioactivity in each region, relative to the concentration in the whole brain slice; (c) Schematic representation of the mouse brain (sagittal view). The positions of the different Bregma values for which autoradiography images are shown in (a) are indicated with red lines.
