Figure 1

Significant changes in the structural connectivity of patients with pediatric bipolar disorder (PBD) with psychosis, compared to healthy controls (HC). Connected component of significant differences in structural connectivity strength between patients with PBD and HC, represented with edges connecting a pair of regions. (A) Binarised version of the connected network of significantly altered structural connectivity in PBD. (B) Weighted version of (A), where the edge thickness represents the amplitude of the differences in structural connectivity. Decreases and increases in connectivity strength between regions in the PBD group are represented in blue and red respectively. PBD primarily differs from HC in inferior temporal networks (e.g. left and right temporal pole to left and right amygdala, left amygdala to left parahippocampal region) and inferior frontal networks (e.g. right orbitofrontal cortex) and subcortical to inferior frontal regions (e.g. right caudate to orbitofrontal cortex and left pallidum to left orbitofrontal cortex).